JADE1 and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		JADE1	HMOX2
Description		jade family PHD finger 1	heme oxygenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Speck Ciliary Basal Body	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Growth Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis
Pathways		HATs acetylate histones	Heme degradation Neutrophil degranulation Iron uptake and transport
Drugs			NADH Stannsoporfin
Diseases
GWAS		Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)	Erectile dysfunction ( 30583798)
Interacting Genes		15 interacting genes: AKT1 AP2M1 CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2	35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		79960	3163
HPRD ID		10151	00783
Ensembl ID		ENSG00000077684	ENSG00000103415
Uniprot IDs		B4E2E2 Q6IE81	A0A087WT44 B3KSE0 P30519
PDB IDs			2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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