TSC2 and RABEP1

Number of citations of the paper that reports this interaction (PubMedID 9045618)
60

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TSC2	RABEP1
Description		TSC complex subunit 2	rabaptin, RAB GTPase binding effector protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs	TBC/RABGAPs
Drugs
Diseases		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Major depressive disorder ( 29317602) Obesity-related traits ( 23251661)	Body mass index ( 28892062 25673413) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)
Interacting Genes		42 interacting genes: AKT1 AKT2 AKT3 CALM1 CBY2 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SUPT6H TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	24 interacting genes: AP1G1 AP1G2 ATXN7 CASP3 CCND1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 ITSN2 RAB1A RAB33B RAB4A RAB5A RABGEF1 RGS17 SMURF1 SRPK2 TRIM26 TSC2 UBC YWHAG
Entrez ID		7249	9135
HPRD ID		01850	04684
Ensembl ID		ENSG00000103197	ENSG00000029725
Uniprot IDs		B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2	B4DMM4 Q15276
PDB IDs			1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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