TPM1 and TPM4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical)

		TPM1	TPM4
Description		tropomyosin 1	tropomyosin 4
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Muscle Filament Sliding
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Artenimol Phenethyl Isothiocyanate	Phenethyl Isothiocyanate
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 27863252) Orofacial clefts ( 22863734) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Pulse pressure ( 27841878)	Mean platelet volume ( 31080455 22139419 22423221 27863252) Platelet count ( 26805783 22139419 22423221 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		21 interacting genes: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 IFIT3 JUN KXD1 MAD1L1 NEB NOD2 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4	9 interacting genes: LNX1 NOD2 PACSIN1 PRKACA RAB8A SMURF1 TCERG1 TPM1 TRIP6
Entrez ID		7168	7171
HPRD ID		01839	11734
Ensembl ID		ENSG00000140416	ENSG00000167460
Uniprot IDs		A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493	A0A5F9UN72 K7ENT6 P67936 V9HW56
PDB IDs		3MUD 5KHT
Enriched GO Terms of Interacting Partners?
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