TLN1 and PTK2

Number of citations of the paper that reports this interaction (PubMedID 7622520)
100

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		TLN1	PTK2
Description		talin 1	protein tyrosine kinase 2
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cell Cytosol Cytoskeleton Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Dendritic Spine Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding
	Biological Process	Platelet Degranulation Muscle Contraction Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation	MAPK Cascade Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Nuclear Migration Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Negative Regulation Of Autophagy Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Wound Healing Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Signal regulatory protein family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis
Drugs			7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Diseases
GWAS		IgE levels in asthmatics ( 23967269) Platelet distribution width ( 27863252)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Atrial fibrillation ( 30061737 29892015) Diastolic blood pressure ( 30224653) Mean corpuscular hemoglobin ( 27863252) Mood instability ( 31168069) Nickel levels ( 26025379) Response to interferon beta therapy ( 21502966) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		26 interacting genes: ACTA1 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ	112 interacting genes: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 DOK4 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTEN PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SH2D1A SH2D1B SHC1 SOCS1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TNS3 TP53 TRIM15 TRIO TRIP6 TSC2 VCL YES1 ZFYVE21 ZNF331
Entrez ID		7094	5747
HPRD ID		01726	02859
Ensembl ID		ENSG00000137076	ENSG00000169398
Uniprot IDs		Q9Y490	Q05397 Q59GM6 Q59GN8 Q658W2
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S 6I8Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?