TLN1 and VCL

Number of citations of the paper that reports this interaction (PubMedID 15070891)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		TLN1	VCL
Description		talin 1	vinculin
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cell Cytosol Cytoskeleton Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Podosome Extracellular Region Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Costamere Cell-cell Contact Zone Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Platelet Degranulation Muscle Contraction Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation	Morphogenesis Of An Epithelium Platelet Degranulation Muscle Contraction Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Apical Junction Assembly Neutrophil Degranulation Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Cell-cell Adherens Junction
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		IgE levels in asthmatics ( 23967269) Platelet distribution width ( 27863252)	Cardiac troponin-I levels ( 31014085) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)
Interacting Genes		26 interacting genes: ACTA1 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ	30 interacting genes: ABI2 ACTA1 ACTN1 C19orf57 CDH1 CLTC CORO2B CTNNA1 GSN ITGA5 LPXN NRAP PKD1 PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SELE SORBS1 SORBS2 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP
Entrez ID		7094	7414
HPRD ID		01726	01900
Ensembl ID		ENSG00000137076	ENSG00000035403
Uniprot IDs		Q9Y490	A0A024QZN4 B3KXA2 P18206 V9HWK2
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY
Enriched GO Terms of Interacting Partners?
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