TLN1 and ITGA1

Number of citations of the paper that reports this interaction (PubMedID 11336656)
6

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		TLN1	ITGA1
Description		talin 1	integrin subunit alpha 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cell Cytosol Cytoskeleton Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Signaling Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Platelet Degranulation Muscle Contraction Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen
Drugs
Diseases
GWAS		IgE levels in asthmatics ( 23967269) Platelet distribution width ( 27863252)	Acne (severe) ( 24927181) Alzheimer's disease biomarkers ( 23419831) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30224653 30578418) Response to platinum-based agents ( 22020760) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein level ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 30130595 30718926 29926116)
Interacting Genes		26 interacting genes: ACTA1 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ	10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		7094	3672
HPRD ID		01726	01892
Ensembl ID		ENSG00000137076	ENSG00000213949
Uniprot IDs		Q9Y490	P56199
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
Enriched GO Terms of Interacting Partners?
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