TK1 and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TK1	ALAS1
Description		thymidine kinase 1	5'-aminolevulinate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Phosphorylation Pyrimidine Nucleoside Salvage Thymidine Metabolic Process Protein Homotetramerization DNA Biosynthetic Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Dithioerythritol Thymidine-5'-Triphosphate	Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red cell distribution width ( 27863252 28957414)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		160 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DCAF7 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		7083	211
HPRD ID		01771	00505
Ensembl ID		ENSG00000167900	ENSG00000023330
Uniprot IDs		A0A384MDV9 K7ES52 P04183	B4DVA0 P13196 Q5JAM2
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?
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