TK1 and JMJD1C

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TK1	JMJD1C
Description		thymidine kinase 1	jumonji domain containing 1C
Image
GO Annotations	Cellular Component	Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Phosphorylation Pyrimidine Nucleoside Salvage Thymidine Metabolic Process Protein Homotetramerization DNA Biosynthetic Process	Regulation Of Transcription, DNA-templated Blood Coagulation Histone H3-K9 Demethylation Oxidation-reduction Process
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Factors involved in megakaryocyte development and platelet production
Drugs		Dithioerythritol Thymidine-5'-Triphosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red cell distribution width ( 27863252 28957414)	Androgen levels ( 22936694) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 27863252) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Mean platelet volume ( 22139419 24026423 19820697 31194788 27863252) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 26805783 22139419 24026423 23263863 22423221 27863252) Platelet distribution width ( 27863252) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 31666285 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 28334899 29403010) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 28406950) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252)
Interacting Genes		160 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DCAF7 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	13 interacting genes: AR ESR2 GADD45A MT2A NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1
Entrez ID		7083	221037
HPRD ID		01771	05141
Ensembl ID		ENSG00000167900	ENSG00000171988
Uniprot IDs		A0A384MDV9 K7ES52 P04183	B7ZLC8 Q15652
PDB IDs		1W4R 1XBT 2ORV 2WVJ	2YPD 5FZO
Enriched GO Terms of Interacting Partners?
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