THY1 and ATXN7

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid)

		THY1	ATXN7
Description		Thy-1 cell surface antigen	ataxin 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Growth Cone Axolemma Anchored Component Of External Side Of Plasma Membrane Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding Protein Kinase Binding GPI Anchor Binding	Protein Binding
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Integrin-mediated Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Retinal Cone Cell Development Protein Autophosphorylation Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)
Interacting Genes		8 interacting genes: ATXN1L ATXN7 CLK1 FYN ITGAM ITGAV ITGB3 LCK	60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF
Entrez ID		7070	6314
HPRD ID		01769	06365
Ensembl ID		ENSG00000154096	ENSG00000163635
Uniprot IDs		B0YJA4 P04216	O15265 Q9UPD8
PDB IDs			2KKR
Enriched GO Terms of Interacting Partners?
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