KPNA4 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 19801544)
41

Data Source:
BioGRID (pull down)

		KPNA4	CUL4B
Description		karyopherin subunit alpha 4	cullin 4B
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GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Nuclear Membrane	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Response To Hydrogen Peroxide	G1/S Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Ribosome Biogenesis DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Global Genome Nucleotide-excision Repair UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		20 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 GTF2IRD1 HIF1A HNRNPC KPNB1 MAT2B NTRK3 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1	25 interacting genes: AHR APP AR CAND1 COMMD1 DCUN1D4 DDB1 DDB2 DNMT3B ESR1 HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PRDX3 PTEN RBX1 RNF7 SALL2 SIN3A TBL3 UBC UBE2D3 ZMAT4
Entrez ID		3840	8450
HPRD ID		04275	02251
Ensembl ID		ENSG00000186432	ENSG00000158290
Uniprot IDs		O00629	K4DI93 Q13620
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB	2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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