TDO2 and SDCBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TDO2	SDCBP2
Description		tryptophan 2,3-dioxygenase	syndecan binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleolus Cytoplasm Plasma Membrane Nuclear Speck Extracellular Exosome
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Oxidation-reduction Process Response To Nitroglycerin	Nervous System Development Cell Proliferation Intracellular Signal Transduction Intracellular Transport
Pathways		Tryptophan catabolism
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)	Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA MEOX2 MOB1A MOB3C NGB NMNAT1 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	44 interacting genes: ADAP1 ARF4 BEND7 C1orf35 CT45A3 CT45A5 CTH DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 LGALS14 LGALS2 LYAR MED4 NFASC NKAPD1 NPM2 NRXN1 NUF2 PAFAH1B3 PRPF38A PRPF40A PRR13 PTMS RNPS1 RPL22 SDCBP SEC23A SREK1IP1 TDO2 THAP6 TIFA TM4SF1 TNP1 TRAF1 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2
Entrez ID		6999	27111
HPRD ID		01847	18032
Ensembl ID		ENSG00000151790	ENSG00000125775
Uniprot IDs		P48775	Q9H190
PDB IDs		4PW8 5TI9 5TIA 6A4I
Enriched GO Terms of Interacting Partners?
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