TDO2 and NMNAT1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		TDO2	NMNAT1
Description		tryptophan 2,3-dioxygenase	nicotinamide nucleotide adenylyltransferase 1
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Oxidation-reduction Process Response To Nitroglycerin	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose
Pathways		Tryptophan catabolism	Nicotinate metabolism
Drugs			Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)	Resting heart rate ( 27798624)
Interacting Genes		16 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA MEOX2 MOB1A MOB3C NGB NMNAT1 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	12 interacting genes: APP BANP CCNC FLOT2 KPNA2 MSX1 NEK3 NTRK2 PABPC4 SIK1 SIRT1 TDO2
Entrez ID		6999	64802
HPRD ID		01847	16369
Ensembl ID		ENSG00000151790	ENSG00000173614
Uniprot IDs		P48775	A0A024R4E1 B1AN62 Q9HAN9
PDB IDs		4PW8 5TI9 5TIA 6A4I	1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?
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