MLX and MLXIPL

Number of citations of the paper that reports this interaction (PubMedID 14742444)
65

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MLX	MLXIPL
Description		MAX dimerization protein MLX	MLX interacting protein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Nuclear Chromatin Cell Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Birth weight ( 31043758 27680694) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 25288136) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertriglyceridemia ( 27599772 23505323 20657596) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Platelet count ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum albumin level ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211 29403010) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 21909109 18193043 18193044 18193046 20864672 26160806 19060906 19060911 30275531 25961943 20686565 26582766) Urate levels ( 31578528 23263486) Urinary sodium excretion ( 31409800) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		14 interacting genes: APP GABARAPL2 ID3 LNX2 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP TLE5 ZBTB32	5 interacting genes: CIT CLCC1 GRB2 MLX NIF3L1
Entrez ID		6945	51085
HPRD ID		04278	12033
Ensembl ID		ENSG00000108788	ENSG00000009950
Uniprot IDs		Q9UH92	Q9NP71
PDB IDs
Enriched GO Terms of Interacting Partners?
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