TAL1 and SP1

Number of citations of the paper that reports this interaction (PubMedID 12239153)
55

Data Source:
BioGRID (pull down, two hybrid, affinity chromatography technology)
HPRD (in vitro, in vivo)

		TAL1	SP1
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	Sp1 transcription factor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Lsd1/2 Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Stem Cell Population Maintenance Positive Regulation Of Signaling Receptor Activity	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Viral Process Cellular Response To Insulin Stimulus Response To Hydroperoxide SnRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation By Host Of Viral Transcription Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular volume ( 27863252)	Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 27863252) Reticulocyte count ( 27863252)
Interacting Genes		24 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STOML2 STUB1 TCF3 TCF4 ZHX1	145 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEPRO NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 USP39 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB7A
Entrez ID		6886	6667
HPRD ID		01753	01796
Ensembl ID		ENSG00000162367	ENSG00000185591
Uniprot IDs		P17542 Q16509	P08047
PDB IDs		2YPA 2YPB	1SP1 1SP2 1VA1 1VA2 1VA3
Enriched GO Terms of Interacting Partners?
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