TAL1 and ELSPBP1

Number of citations of the paper that reports this interaction (PubMedID 8159721)
35

Data Source:
HPRD (two hybrid, in vivo)

		TAL1	ELSPBP1
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	epididymal sperm binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Lsd1/2 Complex	Extracellular Region Cell Surface
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding	Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Stem Cell Population Maintenance Positive Regulation Of Signaling Receptor Activity	Single Fertilization Sperm Capacitation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs			N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular volume ( 27863252)	Intelligence ( 22449649) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627)
Interacting Genes		24 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STOML2 STUB1 TCF3 TCF4 ZHX1	4 interacting genes: MYOD1 NEDD9 PSMD9 TAL1
Entrez ID		6886	64100
HPRD ID		01753	12119
Ensembl ID		ENSG00000162367	ENSG00000169393
Uniprot IDs		P17542 Q16509	A0A384NKL6 Q96BH3
PDB IDs		2YPA 2YPB
Enriched GO Terms of Interacting Partners?
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