TAL1 and STUB1

Number of citations of the paper that reports this interaction (PubMedID 17962192)
12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		TAL1	STUB1
Description		TAL bHLH transcription factor 1, erythroid differentiation factor	STIP1 homology and U-box containing protein 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Lsd1/2 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Stem Cell Population Maintenance Positive Regulation Of Signaling Receptor Activity	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Downregulation of TGF-beta receptor signaling Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular volume ( 27863252)
Interacting Genes		24 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STOML2 STUB1 TCF3 TCF4 ZHX1	123 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP
Entrez ID		6886	10273
HPRD ID		01753	06232
Ensembl ID		ENSG00000162367	ENSG00000103266
Uniprot IDs		P17542 Q16509	Q9UNE7
PDB IDs		2YPA 2YPB	4KBQ 6EFK 6NSV
Enriched GO Terms of Interacting Partners?
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