SUPT5H and MAD1L1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		SUPT5H	MAD1L1
Description		SPT5 homolog, DSIF elongation factor subunit	mitotic arrest deficient 1 like 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Negative Regulation Of MRNA Polyadenylation	Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Adverse response to drug ( 30420678) Age at first sexual intercourse ( 27089180) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 28115744 21926972 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dimensional psychopathology (Social) ( 29496196) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Number of sexual partners ( 30643258) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		44 interacting genes: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CEP55 CSNK2A1 DBN1 DCAF6 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B	40 interacting genes: ALOX5 AMOTL2 BIRC2 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PML PSMA1 RNF8 SIN3A SIN3B SPATA2 SUPT5H TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		6829	8379
HPRD ID		03655	04065
Ensembl ID		ENSG00000196235	ENSG00000002822
Uniprot IDs		O00267	Q9Y6D9
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML	1GO4 4DZO
Enriched GO Terms of Interacting Partners?
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