MAD1L1 and HAUS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAD1L1	HAUS1
Description		mitotic arrest deficient 1 like 1	HAUS augmin like complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole	Spindle Pole Centrosome Cytosol Microtubule HAUS Complex
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Molecular_function Protein Binding
	Biological Process	Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression	G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Age at first sexual intercourse ( 27089180) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 28115744 21926972 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dimensional psychopathology (Social) ( 29496196) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Number of sexual partners ( 30643258) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		40 interacting genes: ALOX5 AMOTL2 BIRC2 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PML PSMA1 RNF8 SIN3A SIN3B SPATA2 SUPT5H TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	68 interacting genes: AK8 ARFIP2 BLOC1S6 C3orf62 CAGE1 CBY2 CCDC114 CCDC136 CCDC57 CCHCR1 CDR2 CEP170P1 CEP44 CEP55 CEP57L1 CEP63 CEP70 DCTN2 DMD DTNBP1 FGFR1OP2 GOLGA2 HOOK2 IFIT3 IFT20 INCA1 KDM1A KIFC3 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KXD1 LDOC1 LURAP1 MAD1L1 MAGEA6 MCM10 MCM3 MED4 MED7 MIPOL1 MTUS2 NDC80 NECAB2 NINL NUP54 NUP62 PDE4DIP PIBF1 SPAG5 STX11 SYCE1 SYCE3 TFIP11 TFPT TRAF1 TRIM23 TRIM27 TRIM54 TRIM69 TSG101 USHBP1 VPS52 WASHC3 ZNF471
Entrez ID		8379	115106
HPRD ID		04065	16385
Ensembl ID		ENSG00000002822	ENSG00000152240
Uniprot IDs		Q9Y6D9	Q96CS2
PDB IDs		1GO4 4DZO
Enriched GO Terms of Interacting Partners?
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