MAD1L1 and CWF19L2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAD1L1	CWF19L2
Description		mitotic arrest deficient 1 like 1	CWF19 like cell cycle control factor 2
Image
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole	Post-mRNA Release Spliceosomal Complex
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression	MRNA Splicing, Via Spliceosome
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Age at first sexual intercourse ( 27089180) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 28115744 21926972 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dimensional psychopathology (Social) ( 29496196) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Number of sexual partners ( 30643258) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604728 28604732 23666239)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Coronary artery disease ( 29212778) Cortex volume ( 31530798) Diastolic blood pressure ( 27841878) Fourth ventricle volume ( 31530798) Pars opercularis volume ( 31530798) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		40 interacting genes: ALOX5 AMOTL2 BIRC2 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PML PSMA1 RNF8 SIN3A SIN3B SPATA2 SUPT5H TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	28 interacting genes: APP BRCA1 CALCOCO1 CALCOCO2 CARD9 CCDC136 CCDC57 FAM9B HOOK2 KRT40 LHX9 LMNA LZTS2 MAD1L1 MEOX1 MTUS2 NAB2 NDEL1 RINT1 SF3B4 STX11 TAX1BP1 TP53BP2 TRIM27 TRIM37 TRIM54 TRIM9 VIM
Entrez ID		8379	143884
HPRD ID		04065	13102
Ensembl ID		ENSG00000002822	ENSG00000152404
Uniprot IDs		Q9Y6D9	Q2TBE0
PDB IDs		1GO4 4DZO	6ID0 6ID1
Enriched GO Terms of Interacting Partners?
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