STK11 and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		STK11	CCNE1
Description		serine/threonine kinase 11	cyclin E1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity	Transcription Coactivator Activity Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatogenesis Axonogenesis Negative Regulation Of Cell Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Synapsis Wnt Signaling Pathway Androgen Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Localization
Pathways		AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle
Drugs
Diseases		Peutz-Jeghers syndrome Pancreatic cancer	Laryngeal cancer Gastric cancer
GWAS		Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Psychosis in Alzheimer's disease ( 22005930)	Bladder cancer ( 24163127 20972438) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 28135244 27841878) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458)
Interacting Genes		113 interacting genes: ABCB5 ADIPOR1 AKT1 APP ARAF ARG2 ARNT ATM AURKA BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCND2 CCNE1 CD44 CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A KAT2A KDELR2 KLK7 LATS2 LYPD3 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB TBC1D23 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 YWHAG	68 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A LATS2 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		6794	898
HPRD ID		03740	00455
Ensembl ID		ENSG00000118046	ENSG00000105173
Uniprot IDs		A0A0S2Z4D1 Q15831	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		2WTK 4ZDR 5WXN	1W98 5L2W
Enriched GO Terms of Interacting Partners?
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