STK11 and SMARCA4

Number of citations of the paper that reports this interaction (PubMedID 14676191)
55

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)
HPRD (in vivo, in vitro)

		STK11	SMARCA4
Description		serine/threonine kinase 11	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Transcription Factor Binding Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatogenesis Axonogenesis Negative Regulation Of Cell Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Interleukin-7-mediated Signaling Pathway ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Beta-catenin-TCF Complex Assembly
Pathways		AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Peutz-Jeghers syndrome Pancreatic cancer
GWAS		Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Psychosis in Alzheimer's disease ( 22005930)	Coronary artery disease ( 24262325 30104761) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Inflammatory skin disease ( 25574825) Ischemic stroke ( 29531354) LDL cholesterol ( 21347282) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 31604244) Stroke ( 29531354)
Interacting Genes		113 interacting genes: ABCB5 ADIPOR1 AKT1 APP ARAF ARG2 ARNT ATM AURKA BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCND2 CCNE1 CD44 CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A KAT2A KDELR2 KLK7 LATS2 LYPD3 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB TBC1D23 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 YWHAG	78 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 E2F6 ESR1 ETS2 FANCA GATA1 GMNN H2AX H2BC21 H3-3A H3C1 H3C14 H4C6 HSF1 HSF4 HSPB1 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MPHOSPH6 MPP6 MRTFA MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 TAF15 TMF1 TP53 ZMYND11
Entrez ID		6794	6597
HPRD ID		03740	04459
Ensembl ID		ENSG00000118046	ENSG00000127616
Uniprot IDs		A0A0S2Z4D1 Q15831	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		2WTK 4ZDR 5WXN	2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2
Enriched GO Terms of Interacting Partners?
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