STK11 and CYP17A1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		STK11	CYP17A1
Description		serine/threonine kinase 11	cytochrome P450 family 17 subfamily A member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Axon Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatogenesis Axonogenesis Negative Regulation Of Cell Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process Oxidation-reduction Process
Pathways		AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Drugs			NADH Progesterone Abiraterone
Diseases		Peutz-Jeghers syndrome Pancreatic cancer	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Psychosis in Alzheimer's disease ( 22005930)	Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 24001895 21909110) Colorectal cancer ( 26965516) Coronary artery disease ( 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 28739976 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 31879980 25249183 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 27841878 28739976 30487518) Schizophrenia ( 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 26390057 27736895 28135244 19430479 19430483 27841878 21909115 28739976 27618447 27618452 25249183 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		113 interacting genes: ABCB5 ADIPOR1 AKT1 APP ARAF ARG2 ARNT ATM AURKA BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCND2 CCNE1 CD44 CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A KAT2A KDELR2 KLK7 LATS2 LYPD3 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB TBC1D23 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 YWHAG	15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7
Entrez ID		6794	1586
HPRD ID		03740	01944
Ensembl ID		ENSG00000118046	ENSG00000148795
Uniprot IDs		A0A0S2Z4D1 Q15831	P05093 Q1HB44
PDB IDs		2WTK 4ZDR 5WXN	2C17 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ
Enriched GO Terms of Interacting Partners?
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