STAT5B and KIT

Number of citations of the paper that reports this interaction (PubMedID 10358045)
18

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		STAT5B	KIT
Description		signal transducer and activator of transcription 5B	KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Acrosomal Vesicle Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Mast Cell Granule Receptor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Protein Dimerization Activity	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Cytokine Binding SH2 Domain Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration	MAPK Cascade Activation Of MAPK Activity Ovarian Follicle Development Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Lamellipodium Assembly Hemopoiesis B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Hematopoietic Stem Cell Migration Megakaryocyte Development Fc Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Tongue Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Response To Cadmium Ion Protein Autophosphorylation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Regulation Of Bile Acid Metabolic Process Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Vascular Smooth Muscle Cell Differentiation
Pathways		Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Growth hormone receptor signaling Growth hormone receptor signaling	PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs		Dasatinib	Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 ABT-869 Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Amuvatinib
Diseases		Growth hormone insensitivity with immunodeficiency	Piebaldism Acute myeloid leukemia (AML)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)	Anorexia nervosa or obsessive-compulsive disorder ( 30087453) Bipolar disorder ( 19416921) Breastfeeding duration ( 25475840) Cadmium levels ( 26025379) Hematocrit ( 29403010 28017375) Hemoglobin ( 29403010) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 29403010 28453575 28017375) Mean corpuscular volume ( 29403010 28453575 20139978 28017375 19862010) Platelet count ( 29403010) Red blood cell count ( 29403010 28453575 28017375) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum VEGFR2 concentration ( 25411163) Systemic lupus erythematosus ( 29494758)
Interacting Genes		49 interacting genes: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG	60 interacting genes: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX TEC YES1
Entrez ID		6777	3815
HPRD ID		05037	01287
Ensembl ID		ENSG00000173757	ENSG00000157404
Uniprot IDs		P51692	A0A0U2N547 P10721
PDB IDs		6MBW 6MBZ	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB
Enriched GO Terms of Interacting Partners?
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