STAT5B and ETS1

Number of citations of the paper that reports this interaction (PubMedID 10815800)
12

Data Source:
HPRD (in vitro, in vivo)

		STAT5B	ETS1
Description		signal transducer and activator of transcription 5B	ETS proto-oncogene 1, transcription factor
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Protein Dimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding
	Biological Process	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Immune Response Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development Cell Differentiation PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Positive Regulation Of Blood Vessel Endothelial Cell Migration Estrous Cycle Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Motility Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Growth hormone receptor signaling Growth hormone receptor signaling	Oncogene Induced Senescence
Drugs		Dasatinib
Diseases		Growth hormone insensitivity with immunodeficiency
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 22057235 20190752 25920553) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 30423114 22446963 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 20169177 28714469 19838193) Type 2 diabetes ( 30054458 30297969 30718926) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)
Interacting Genes		49 interacting genes: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG	50 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		6777	2113
HPRD ID		05037	01260
Ensembl ID		ENSG00000173757	ENSG00000134954
Uniprot IDs		P51692	A8K725 B4DW78 P14921
PDB IDs		6MBW 6MBZ	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?
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