SSR1 and DKC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SSR1	DKC1
Description		signal sequence receptor subunit 1	dyskerin pseudouridine synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	Protein Binding	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation IRE1-mediated Unfolded Protein Response	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA SnoRNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis
Pathways		SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Ewing sarcoma ( 30093639) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 24509480 30718926 28869590)
Interacting Genes		9 interacting genes: DKC1 EEF1A1 HSPA13 NPC2 NUP54 ODC1 PTN SERPINF2 UTP14A	11 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC
Entrez ID		6745	1736
HPRD ID		02924	02129
Ensembl ID		ENSG00000124783	ENSG00000130826
Uniprot IDs		C9JBX5 P43307	O60832
PDB IDs
Enriched GO Terms of Interacting Partners?
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