DKC1 and SSR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DKC1	SSR1
Description		dyskerin pseudouridine synthase 1	signal sequence receptor subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding	Protein Binding
	Biological Process	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA SnoRNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation IRE1-mediated Unfolded Protein Response
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs
Diseases		Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS			Ewing sarcoma ( 30093639) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 24509480 30718926 28869590)
Interacting Genes		11 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC	9 interacting genes: DKC1 EEF1A1 HSPA13 NPC2 NUP54 ODC1 PTN SERPINF2 UTP14A
Entrez ID		1736	6745
HPRD ID		02129	02924
Ensembl ID		ENSG00000130826	ENSG00000124783
Uniprot IDs		O60832	C9JBX5 P43307
PDB IDs
Enriched GO Terms of Interacting Partners?
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