DKC1 and SHQ1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		DKC1	SHQ1
Description		dyskerin pseudouridine synthase 1	SHQ1, H/ACA ribonucleoprotein assembly factor
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA SnoRNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis	Box H/ACA SnoRNP Assembly Ribonucleoprotein Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Negative Regulation Of RRNA Processing
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases		Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS			Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)
Interacting Genes		11 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC	3 interacting genes: DKC1 GMCL1 GMCL2
Entrez ID		1736	55164
HPRD ID		02129	07682
Ensembl ID		ENSG00000130826	ENSG00000144736
Uniprot IDs		O60832	Q6PI26
PDB IDs			2MNW 4PBD 4PCK
Enriched GO Terms of Interacting Partners?
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