SSR1 and NPC2

		SSR1	NPC2
Description		signal sequence receptor subunit 1	NPC intracellular cholesterol transporter 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Intermembrane Cholesterol Transfer Activity
	Biological Process	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation IRE1-mediated Unfolded Protein Response	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport
Pathways		SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes	Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Ewing sarcoma ( 30093639) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 24509480 30718926 28869590)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993)
Interacting Genes		9 interacting genes: DKC1 EEF1A1 HSPA13 NPC2 NUP54 ODC1 PTN SERPINF2 UTP14A	19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1
Entrez ID		6745	10577
HPRD ID		02924	03008
Ensembl ID		ENSG00000124783	ENSG00000119655
Uniprot IDs		C9JBX5 P43307	A0A024R6C0 P61916
PDB IDs			5KWY
Enriched GO Terms of Interacting Partners?
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