NPC2 and USP4

Number of citations of the paper that reports this interaction (PubMedID 23022198)
4

Data Source:
BioGRID (two hybrid)

		NPC2	USP4
Description		NPC intracellular cholesterol transporter 2	ubiquitin specific peptidase 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Intermembrane Cholesterol Transfer Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface
Pathways		Neutrophil degranulation LDL clearance	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1	47 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A CIAO2B HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		10577	7375
HPRD ID		03008	04598
Ensembl ID		ENSG00000119655	ENSG00000114316
Uniprot IDs		A0A024R6C0 P61916	A0A024R2X6 A1LPW7 Q08AK7 Q13107
PDB IDs		5KWY	2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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