SPINK2 and ADAMTSL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPINK2	ADAMTSL4
Description		serine peptidase inhibitor Kazal type 2	ADAMTS like 4
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region	Interstitial Matrix Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Protease Binding Protein Binding Peptidase Activity
	Biological Process	Acrosome Assembly Spermatid Development Negative Regulation Of Serine-type Endopeptidase Activity	Epithelial Cell Development Proteolysis Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process
Pathways			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Ectopia lentis
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Blood protein levels ( 30072576 29875488) Migraine ( 27322543) Post bronchodilator FEV1/FVC ratio ( 26634245) Stroke ( 26089329) Systemic sclerosis ( 30247649)	Coronary artery disease ( 29212778) Migraine ( 27322543) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		6 interacting genes: ADAMTSL4 CEP135 KRTAP10-3 KRTAP5-9 MAPK8IP2 NOTCH2NLA	110 interacting genes: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 CATSPER1 CCDC26 CFAP206 CHCHD2 CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL2 GNE GNMT GOLGA8EP HGF HNRNPLL HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LHX4 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 OTX1 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SHFL SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		6691	54507
HPRD ID		10422	18237
Ensembl ID		ENSG00000128040	ENSG00000143382
Uniprot IDs		A0A024RD95 A0A087WTA9 D6RC51 D6RI10 P20155	B7ZMJ3 Q6UY14 Q9UFG7
PDB IDs		2JXD 6KBR
Enriched GO Terms of Interacting Partners?
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