SMARCC1 and PRMT5

Number of citations of the paper that reports this interaction (PubMedID 14559996)
113

Data Source:
BioGRID (pull down)

		SMARCC1	PRMT5
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	protein arginine methyltransferase 5
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GO Annotations	Cellular Component	Nuclear Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048)	Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		26 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB EWSR1 FANCA FUS GATA1 ITCH KLF1 MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PRMT5 RELB SIN3A SMARCA4 SMARCD3 SP1 TAF15	79 interacting genes: ARGLU1 CALU CAPN1 CCAR2 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EZH2 FAM76B GLI1 GRHL3 GTPBP2 H2AC20 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		6599	10419
HPRD ID		03435	04955
Ensembl ID		ENSG00000173473	ENSG00000100462
Uniprot IDs		Q58EY4 Q92922	B4DV00 O14744
PDB IDs		2YUS 5GJK	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S
Enriched GO Terms of Interacting Partners?
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