UBE2Z and HLTF

Number of citations of the paper that reports this interaction (PubMedID 19690564)
57

Data Source:
BioGRID (two hybrid)

		UBE2Z	HLTF
Description		ubiquitin conjugating enzyme E2 Z	helicase like transcription factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		34 interacting genes: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 OTUB1 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA1 UBA6 UBD	14 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4
Entrez ID		65264	6596
HPRD ID		08589	04461
Ensembl ID		ENSG00000159202	ENSG00000071794
Uniprot IDs		Q9H832	A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527
PDB IDs		5A4P	2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F
Enriched GO Terms of Interacting Partners?
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