HLTF and DCAF1

Number of citations of the paper that reports this interaction (PubMedID 29079575)
6

Data Source:
BioGRID (enzymatic study)

		HLTF	DCAF1
Description		helicase like transcription factor	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Estrogen Receptor Binding Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Antigen processing: Ubiquitination & Proteasome degradation
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Diseases
GWAS
Interacting Genes		14 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	20 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IMPDH2 KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2
Entrez ID		6596	9730
HPRD ID		04461	11674
Ensembl ID		ENSG00000071794	ENSG00000145041
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	Q9Y4B6
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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