UBE2Z and SYVN1

Number of citations of the paper that reports this interaction (PubMedID 19690564)
57

Data Source:
BioGRID (two hybrid)

		UBE2Z	SYVN1
Description		ubiquitin conjugating enzyme E2 Z	synoviolin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol IRE1-mediated Unfolded Protein Response ERAD Pathway Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Type 2 diabetes ( 30054458 29358691)	Blood protein levels ( 28240269)
Interacting Genes		34 interacting genes: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 OTUB1 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA1 UBA6 UBD	13 interacting genes: APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2G1 UBE2U UBE2Z USP7
Entrez ID		65264	84447
HPRD ID		08589	07618
Ensembl ID		ENSG00000159202	ENSG00000162298
Uniprot IDs		Q9H832	Q86TM6
PDB IDs		5A4P	6A3Z
Enriched GO Terms of Interacting Partners?
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