SMYD3 and PBX2

Number of citations of the paper that reports this interaction (PubMedID 14667819)
35

Data Source:
HPRD (two hybrid)

		SMYD3	PBX2
Description		SET and MYND domain containing 3	PBX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Transcription Factor Binding
	Biological Process	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Fractional exhaled nitric oxide (childhood) ( 24315451) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)	Advanced age-related macular degeneration ( 26691988) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Crohn's disease ( 23266558) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		17 interacting genes: APP CAMK2B CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K SCCPDH TRIT1 VANGL1 ZNF557	22 interacting genes: BAIAP2 BLOC1S1 CARD9 CCDC88B CENPBD1 COPS6 DCTN3 ELP1 HOXA1 HOXA9 HOXB8 MCRS1 MTREX NEU1 NUP62 PBX1 PKNOX1 RPL4 RPS6KC1 SMYD3 UBE2E1 ZDHHC7
Entrez ID		64754	5089
HPRD ID		12297	08890
Ensembl ID		ENSG00000185420	ENSG00000204304
Uniprot IDs		B3KN46 Q9H7B4	A0A024RCR3 P40425
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL
Enriched GO Terms of Interacting Partners?
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