SMYD3 and H3-5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
38

Data Source:
BioGRID (two hybrid)

		SMYD3	H3-5
Description		SET and MYND domain containing 3	H3.5 histone
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleosome Nucleus Nuclear Euchromatin
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	Positive Regulation Of Cell Growth
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Fractional exhaled nitric oxide (childhood) ( 24315451) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		17 interacting genes: APP CAMK2B CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K SCCPDH TRIT1 VANGL1 ZNF557	12 interacting genes: KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		64754	440093
HPRD ID		12297	18443
Ensembl ID		ENSG00000185420	ENSG00000188375
Uniprot IDs		B3KN46 Q9H7B4	Q6NXT2
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L
Enriched GO Terms of Interacting Partners?
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