SGTA and KRT6A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SGTA	KRT6A
Description		small glutamine rich tetratricopeptide repeat containing alpha	keratin 6A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane	Nucleus Cytosol Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Cytolysis By Symbiont Of Host Cells Morphogenesis Of An Epithelium Cytoskeleton Organization Positive Regulation Of Cell Proliferation Cell Differentiation Keratinization Wound Healing Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cornification Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Keratinization Formation of the cornified envelope
Drugs			Zinc
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Interacting Genes		98 interacting genes: ADIPOQ ADRM1 AGR3 BAG6 BCL2L12 BTC C1QA C1QTNF1 C1QTNF6 C3orf52 CD79B CD99 CD99L2 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KASH5 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NAXD NME3 NR3C1 NXF1 PBXIP1 PCDHA4 PFN2 PGR PIAS1 PLAAT4 PPIB PPIC PPP1R3C PRAP1 PTN RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B	22 interacting genes: CCDC85B DSP GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT31 KRT38 KRT40 LMNA MTUS2 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 WASHC3
Entrez ID		6449	3853
HPRD ID		04568	01011
Ensembl ID		ENSG00000104969	ENSG00000205420
Uniprot IDs		O43765	A0A0S2Z428 P02538
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF	5KI0
Enriched GO Terms of Interacting Partners?
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