SFPQ and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		SFPQ	WBP4
Description		splicing factor proline and glutamine rich	WW domain binding protein 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Speck Dendrite Cytoplasm Paraspeckles RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding E-box Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Activation Of Innate Immune Response Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Histone H3 Deacetylation Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis	mRNA Splicing - Major Pathway
Drugs		Copper Artenimol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Endometrial cancer ( 21499250) Hip circumference ( 28552196)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		29 interacting genes: APBB1 AR CSNK2A1 ERG ESR1 EXOSC5 FHL2 FUS GAS7 H3-4 JPT1 NONO PIN1 PPARG PPP1CA PRPF40A PSPC1 PTBP1 RAC1 SIN3A SMAD5 SNRPA SREK1 TCERG1 TOP1 UBC UBE2I WBP4 ZMYM2	44 interacting genes: BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DIAPH1 DNM2 EFTUD2 EWSR1 FUS HLTF HNRNPK HNRNPU HTATSF1 KHDRBS1 NONO PABPC1 PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B3 SF3B4 SFPQ SNRNP70 SNRPA SNRPB TCERG1 WAS WBP11 WIPF1 XRCC6 ZNF207
Entrez ID		6421	11193
HPRD ID		07284	16086
Ensembl ID		ENSG00000116560	ENSG00000120688
Uniprot IDs		A0A384N5Z8 P23246 Q86VG2	O75554
PDB IDs		4WII 4WIJ 4WIK 5WPA 6NCQ	2DK1 2JXW 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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