CLSPN and RAD9A

Number of citations of the paper that reports this interaction (PubMedID 12766152)
89

Data Source:
HPRD (in vitro, in vivo)

		CLSPN	RAD9A
Description		claspin	RAD9 checkpoint clamp component A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		12 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7	38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		63967	5883
HPRD ID		09257	04788
Ensembl ID		ENSG00000092853	ENSG00000172613
Uniprot IDs		Q9HAW4	Q99638
PDB IDs			3A1J 3G65 3GGR 6HM5
Enriched GO Terms of Interacting Partners?
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