CLSPN and USP20

Number of citations of the paper that reports this interaction (PubMedID 25326330)
17

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CLSPN	USP20
Description		claspin	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends	Ub-specific processing proteases
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7	28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL
Entrez ID		63967	10868
HPRD ID		09257	07505
Ensembl ID		ENSG00000092853	ENSG00000136878
Uniprot IDs		Q9HAW4	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?
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