USP20 and CLSPN

Number of citations of the paper that reports this interaction (PubMedID 25326330)
17

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		USP20	CLSPN
Description		ubiquitin specific peptidase 20	claspin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint
Pathways		Ub-specific processing proteases	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL	12 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7
Entrez ID		10868	63967
HPRD ID		07505	09257
Ensembl ID		ENSG00000136878	ENSG00000092853
Uniprot IDs		Q9Y2K6	Q9HAW4
PDB IDs		6KCZ
Enriched GO Terms of Interacting Partners?
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