PRDM1 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 9887105)
81

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PRDM1	TLE2
Description		PR/SET domain 1	TLE family member 2, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Chromatin DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Promoter-specific Chromatin Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of A Branching Structure Maternal Placenta Development Adaptive Immune Response Heart Valve Development Ventricular Septum Development Germ Cell Development Post-embryonic Development Positive Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Regulation Of NK T Cell Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Regulation of TP53 Expression	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753)
Interacting Genes		11 interacting genes: ATXN1 EXOSC3 H1-1 H3C15 IKZF3 IRF4 KDM1A PIAS1 TLE1 TLE2 TLE5	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		639	7089
HPRD ID		04572	03025
Ensembl ID		ENSG00000057657	ENSG00000065717
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	K7EMK7 Q04725
PDB IDs		3DAL
Enriched GO Terms of Interacting Partners?
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