BDKRB2 and GRK2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vivo, in vitro)

		BDKRB2	GRK2
Description		bradykinin receptor B2	G protein-coupled receptor kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse
	Molecular Function	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis
Drugs		Anatibant Icatibant	ATP
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11	50 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		624	156
HPRD ID		00213	00182
Ensembl ID		ENSG00000168398	ENSG00000173020
Uniprot IDs		P30411	A0A0S2Z392 P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y
Enriched GO Terms of Interacting Partners?
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