GRK2 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vivo, in vitro)

		GRK2	BDKRB2
Description		G protein-coupled receptor kinase 2	bradykinin receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		ATP	Anatibant Icatibant
Diseases
GWAS			Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		50 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		156	624
HPRD ID		00182	00213
Ensembl ID		ENSG00000173020	ENSG00000168398
Uniprot IDs		A0A0S2Z392 P25098	P30411
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y
Enriched GO Terms of Interacting Partners?
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