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ACTB and RAC2
Number of citations of the paper that reports this interaction (PubMedID
11027608
)
13
Data Source:
HPRD
(in vitro, in vivo)
ACTB
RAC2
Description
actin beta
Rac family small GTPase 2
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Cortical Cytoskeleton
Vesicle
Protein-containing Complex
NuA4 Histone Acetyltransferase Complex
Cytoplasmic Ribonucleoprotein Granule
Apical Junction Complex
Calyx Of Held
Synapse
Extracellular Exosome
Tight Junction
Blood Microparticle
Dense Body
Schaffer Collateral - CA1 Synapse
Presynapse
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Ribonucleoprotein Complex
Cell
Nuclear Envelope
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Cell Cortex
Lamellipodium
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Cell Projection
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Tat Protein Binding
Nucleosomal DNA Binding
Identical Protein Binding
Tau Protein Binding
Nitric-oxide Synthase Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Protein Deubiquitination
Substantia Nigra Development
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Protein Binding
Cell Junction Assembly
Adherens Junction Assembly
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ATP-dependent Chromatin Remodeling
Apical Protein Localization
Positive Regulation Of Gene Expression, Epigenetic
Ephrin Receptor Signaling Pathway
Synaptic Vesicle Endocytosis
Cell Motility
Regulation Of Norepinephrine Uptake
Positive Regulation Of Norepinephrine Uptake
Membrane Organization
Platelet Aggregation
Protein Localization To Adherens Junction
Cellular Response To Cytochalasin B
Postsynaptic Actin Cytoskeleton Organization
Regulation Of Protein Localization To Plasma Membrane
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Motor Neuron Axon Guidance
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Regulation Of Hydrogen Peroxide Metabolic Process
Positive Regulation Of Lamellipodium Assembly
Regulation Of Cell-substrate Adhesion
Rac Protein Signal Transduction
Cell Projection Assembly
Actin Cytoskeleton Organization
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of T Cell Proliferation
Regulation Of Mast Cell Degranulation
Engulfment Of Apoptotic Cell
Bone Resorption
Cell Redox Homeostasis
Regulation Of Protein Kinase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Respiratory Burst
Regulation Of Mast Cell Chemotaxis
Lymphocyte Aggregation
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Neutrophil Migration
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
HATs acetylate histones
Prefoldin mediated transfer of substrate to CCT/TriC
Folding of actin by CCT/TriC
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
B-WICH complex positively regulates rRNA expression
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
UCH proteinases
DNA Damage Recognition in GG-NER
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
GPVI-mediated activation cascade
ROS and RNS production in phagocytes
PIP3 activates AKT signaling
Rho GTPase cycle
Constitutive Signaling by Aberrant PI3K in Cancer
PCP/CE pathway
RHO GTPases Activate NADPH Oxidases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Quercetin
Phenethyl Isothiocyanate
Dextromethorphan
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS
Global electrical heterogeneity phenotypes (
29622589
)
Relative hand skill in reading disability (
24068947
)
Graves' disease (
23612905
)
Longevity (
20834067
)
Response to methotrexate in juvenile idiopathic arthritis (
24709693
)
Type 1 diabetes (
25751624
)
Interacting Genes
150 interacting genes:
A2M
ABLIM1
ABRA
ACD
ACTC1
ACTG1
AIMP2
ALOX5
ANXA7
AQP2
AR
ARPC1B
ATF7IP
BBS4
BCL2L1
CAP1
CAPZA1
CCN2
CCT2
CCT4
CCT5
CCT8
CDK5R2
CDKN1A
CDKN2A
CFL1
CFL2
CLIC4
CLNS1A
CNN2
CORO1A
CORO7
COTL1
CPNE1
CPNE2
CPNE4
CSNK1A1
CSNK2B
DMTN
DNASE1
DSTN
DYNLL1
EEF1A1
EHHADH
EMD
EP300
ERG
ESR1
EZR
FABP4
FHL3
FLII
GAPDH
GNA12
GSN
H2AX
HCK
HIP1R
HMMR
HNRNPAB
HNRNPD
HNRNPU
HSD17B4
HSPB2
KHDRBS1
LASP1
LGALS13
LMNA
LMOD1
LRRK2
LYN
MAP1B
MAP2
MAPT
MRGBP
MTNR1A
MX1
MYO18B
MYO1E
MYOC
NCALD
NCF1
NDEL1
NEBL
NOS2
NRAP
NSMAF
NT5E
NTAQ1
P2RX7
PCYT1A
PDLIM5
PFDN1
PFDN4
PFN1
PFN2
PHACTR4
PLD1
PLD2
PLG
POLR2A
POT1
PRKCD
PROSER2
PTN
PTPRF
RAB4A
RAC1
RAC2
RALA
RCC1
RPL10A
S100A11
SAMHD1
SCN10A
SHBG
SMAD3
SMAD9
SMARCA4
SMN1
SPTAN1
SPTB
SPTBN2
SRPK2
SSH1
SSH2
SSH3
STX4
SYNJ2BP
TANC1
TCF12
TGM2
TINF2
TK1
TMSB4X
TMSB4XP1
TMSB4XP4
TNNI2
TPM1
TPM2
TPM3
TRIM15
TTR
UBE3A
VHL
VSNL1
WASF1
WASF2
WASF3
XPO6
23 interacting genes:
ACTB
ADAM22
AFG3L2
AGAP2
ARFIP2
ARHGDIA
ARHGDIB
BRD2
CDC42
CHGB
CHPF
CUL1
DEF6
DOCK2
GDI1
ICMT
NCF2
NOS2
NOXA1
PAK2
RTKN
SMAD1
SMAD4
Entrez ID
60
5880
HPRD ID
00032
03628
Ensembl ID
ENSG00000075624
ENSG00000128340
Uniprot IDs
P60709
Q1KLZ0
A0A024R1P2
P15153
V9H0H7
PDB IDs
3BYH
3D2U
3J82
3LUE
6ANU
6ICT
6ICV
6MBJ
6MBK
6MBL
6OX0
6OX1
6OX2
6OX4
6OX5
1DS6
2W2T
2W2V
2W2X
Enriched GO Terms of Interacting Partners
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