ACTB and HNRNPD

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		ACTB	HNRNPD
Description		actin beta	heterogeneous nuclear ribonucleoprotein D
Image
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Ribonucleoprotein Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	AT DNA Binding Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Morphogenesis Of A Polarized Epithelium Retina Homeostasis Establishment Or Maintenance Of Cell Polarity Axonogenesis Protein Deubiquitination Substantia Nigra Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Protein Binding Cell Junction Assembly Adherens Junction Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Apical Protein Localization Positive Regulation Of Gene Expression, Epigenetic Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Membrane Organization Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Protein Localization To Plasma Membrane	MRNA Splicing, Via Spliceosome Liver Development Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process RNA Metabolic Process Cerebellum Development Regulation Of Telomere Maintenance Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Regulation Of RNA Metabolic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity Hepatocyte Dedifferentiation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Quercetin Phenethyl Isothiocyanate	Artenimol
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Global electrical heterogeneity phenotypes ( 29622589) Relative hand skill in reading disability ( 24068947)	Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		150 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG ESR1 EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RALA RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TCF12 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TTR UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6	88 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPF HNRNPH3 HNRNPK HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TNPO1 TRN-GTT2-7 TSEN34 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		60	3184
HPRD ID		00032	03206
Ensembl ID		ENSG00000075624	ENSG00000138668
Uniprot IDs		P60709 Q1KLZ0	A0A024RDB4 A0A024RDF4 A1LU37 Q14103
PDB IDs		3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX4 6OX5	1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?
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