RAC2 and DEF6

Number of citations of the paper that reports this interaction (PubMedID 15023524)
19

Data Source:
HPRD (in vitro)

		RAC2	DEF6
Description		Rac family small GTPase 2	DEF6 guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding	Protein Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Cell Redox Homeostasis Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Graves' disease ( 23612905) Longevity ( 20834067) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Height ( 18391951) Systemic lupus erythematosus ( 28714469)
Interacting Genes		23 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4	15 interacting genes: APP BEGAIN CDC42 CDC42EP1 EIF4ENIF1 HOMEZ LCK PBXIP1 PLSCR1 PTK2 RAC1 RAC2 RHOA TCF4 ZAP70
Entrez ID		5880	50619
HPRD ID		03628	10869
Ensembl ID		ENSG00000128340	ENSG00000023892
Uniprot IDs		A0A024R1P2 P15153 V9H0H7	Q9H4E7
PDB IDs		1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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