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ACTB and GNA12
Number of citations of the paper that reports this interaction (PubMedID
10787407
)
6
Data Source:
HPRD
(in vivo)
ACTB
GNA12
Description
actin beta
G protein subunit alpha 12
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Cortical Cytoskeleton
Vesicle
Protein-containing Complex
NuA4 Histone Acetyltransferase Complex
Cytoplasmic Ribonucleoprotein Granule
Apical Junction Complex
Calyx Of Held
Synapse
Extracellular Exosome
Tight Junction
Blood Microparticle
Dense Body
Schaffer Collateral - CA1 Synapse
Presynapse
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Ribonucleoprotein Complex
Cytoplasm
Heterotrimeric G-protein Complex
Plasma Membrane
Focal Adhesion
Lateral Plasma Membrane
Brush Border Membrane
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Tat Protein Binding
Nucleosomal DNA Binding
Identical Protein Binding
Tau Protein Binding
Nitric-oxide Synthase Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
G Protein-coupled Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
D5 Dopamine Receptor Binding
Metal Ion Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Protein Deubiquitination
Substantia Nigra Development
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Protein Binding
Cell Junction Assembly
Adherens Junction Assembly
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ATP-dependent Chromatin Remodeling
Apical Protein Localization
Positive Regulation Of Gene Expression, Epigenetic
Ephrin Receptor Signaling Pathway
Synaptic Vesicle Endocytosis
Cell Motility
Regulation Of Norepinephrine Uptake
Positive Regulation Of Norepinephrine Uptake
Membrane Organization
Platelet Aggregation
Protein Localization To Adherens Junction
Cellular Response To Cytochalasin B
Postsynaptic Actin Cytoskeleton Organization
Regulation Of Protein Localization To Plasma Membrane
In Utero Embryonic Development
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Cell Shape
Regulation Of Fibroblast Migration
Cell Differentiation
Platelet Activation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Drug
Embryonic Digit Morphogenesis
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
HATs acetylate histones
Prefoldin mediated transfer of substrate to CCT/TriC
Folding of actin by CCT/TriC
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
B-WICH complex positively regulates rRNA expression
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
UCH proteinases
DNA Damage Recognition in GG-NER
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
G alpha (12/13) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Quercetin
Phenethyl Isothiocyanate
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Global electrical heterogeneity phenotypes (
29622589
)
Relative hand skill in reading disability (
24068947
)
Birth weight (
31043758
27680694
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Daytime sleep phenotypes (
27126917
)
Height (
28552196
20881960
25282103
25429064
19343178
31562340
18391951
20189936
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory bowel disease (
28067908
)
Lateral ventricular volume in normal aging (
30258056
)
Loneliness (linear analysis) (
27629369
)
Monocyte count (
27863252
)
Offspring birth weight (
31043758
)
Platelet count (
27863252
)
Plateletcrit (
27863252
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
28067908
23128233
21297633
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Weight (
28552196
)
White matter integrity (
23218918
)
Interacting Genes
150 interacting genes:
A2M
ABLIM1
ABRA
ACD
ACTC1
ACTG1
AIMP2
ALOX5
ANXA7
AQP2
AR
ARPC1B
ATF7IP
BBS4
BCL2L1
CAP1
CAPZA1
CCN2
CCT2
CCT4
CCT5
CCT8
CDK5R2
CDKN1A
CDKN2A
CFL1
CFL2
CLIC4
CLNS1A
CNN2
CORO1A
CORO7
COTL1
CPNE1
CPNE2
CPNE4
CSNK1A1
CSNK2B
DMTN
DNASE1
DSTN
DYNLL1
EEF1A1
EHHADH
EMD
EP300
ERG
ESR1
EZR
FABP4
FHL3
FLII
GAPDH
GNA12
GSN
H2AX
HCK
HIP1R
HMMR
HNRNPAB
HNRNPD
HNRNPU
HSD17B4
HSPB2
KHDRBS1
LASP1
LGALS13
LMNA
LMOD1
LRRK2
LYN
MAP1B
MAP2
MAPT
MRGBP
MTNR1A
MX1
MYO18B
MYO1E
MYOC
NCALD
NCF1
NDEL1
NEBL
NOS2
NRAP
NSMAF
NT5E
NTAQ1
P2RX7
PCYT1A
PDLIM5
PFDN1
PFDN4
PFN1
PFN2
PHACTR4
PLD1
PLD2
PLG
POLR2A
POT1
PRKCD
PROSER2
PTN
PTPRF
RAB4A
RAC1
RAC2
RALA
RCC1
RPL10A
S100A11
SAMHD1
SCN10A
SHBG
SMAD3
SMAD9
SMARCA4
SMN1
SPTAN1
SPTB
SPTBN2
SRPK2
SSH1
SSH2
SSH3
STX4
SYNJ2BP
TANC1
TCF12
TGM2
TINF2
TK1
TMSB4X
TMSB4XP1
TMSB4XP4
TNNI2
TPM1
TPM2
TPM3
TRIM15
TTR
UBE3A
VHL
VSNL1
WASF1
WASF2
WASF3
XPO6
29 interacting genes:
ACTB
AKAP13
APP
ARAF
ARHGEF11
ARHGEF12
BTK
CDH1
CDH15
CDH2
DRD5
F2R
GNA13
GNB1
HSP90AA1
IL3RA
NAPA
PPP2R1A
PPP5C
PRKCA
PRKCB
PRKCD
PRKCE
RASA2
S1PR4
S1PR5
TBXA2R
TEC
TSHR
Entrez ID
60
2768
HPRD ID
00032
05093
Ensembl ID
ENSG00000075624
ENSG00000146535
Uniprot IDs
P60709
Q1KLZ0
E9PC54
Q03113
Q6ZQV4
PDB IDs
3BYH
3D2U
3J82
3LUE
6ANU
6ICT
6ICV
6MBJ
6MBK
6MBL
6OX0
6OX1
6OX2
6OX4
6OX5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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