DRD4 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 18303015)
29

Data Source:
HPRD (in vivo, two hybrid)

		DRD4	KLHL12
Description		dopamine receptor D4	kelch like family member 12
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	Protein Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Dopamine receptors G alpha (i) signalling events	Degradation of DVL
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Loxapine Remoxipride Pramipexole Promazine Chlorpromazine Amoxapine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Perospirone Pardoprunox
Diseases
GWAS
Interacting Genes		6 interacting genes: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1	46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1
Entrez ID		1815	59349
HPRD ID		00541	13925
Ensembl ID		ENSG00000069696	ENSG00000117153
Uniprot IDs		P21917	Q53G59 Q9H7R2
PDB IDs		5WIU 5WIV	2VPJ
Enriched GO Terms of Interacting Partners?
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