SENP2 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 11997515)
20

Data Source:
HPRD (in vivo, in vitro)

		SENP2	SUMO3
Description		SUMO specific peptidase 2	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity	Protein Binding Enzyme Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Spongiotrophoblast Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Sumoylation Negative Regulation Of DNA Binding
Pathways		SUMO is proteolytically processed	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) PR interval ( 30046033) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)	Delirium ( 29631748)
Interacting Genes		28 interacting genes: AGTRAP APP ARL6IP1 AXIN1 CDCA5 CDK5RAP2 DAXX FUNDC1 FZR1 IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TPD52 TRIM63	47 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FOS HIPK2 HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1
Entrez ID		59343	6612
HPRD ID		07002	03754
Ensembl ID		ENSG00000163904	ENSG00000184900
Uniprot IDs		Q9HC62	P55854
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK	1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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